Week 3 of the NFL season is here following another action-packed weekend on the gridiron. Prior to the two Monday Night games, Week 2 saw underdogs go an impressive 9-3-1 against the spread while favorites went 7-6 straight up. On the season, underdogs have been the way to go so far, posting a 17-11-1 ATS record. Regarding totals, UNDERS have been more profitable than OVERS through the first two weeks, and if you're blindly betting UNDERS at closing, you've gone 20-9-1.
Week 3 kicks off with an AFC North clash between the 1-1 Cleveland Browns (-4) and the 1-1 Pittsburgh Steelers in the second edition of Thursday night football on Amazon Prime. On Sunday, we have what should be another entertaining 14-game slate beginning at 1 p.m. ET where bettors are hoping to profit off of sides, totals, money lines, and player props. Remember that these lines will move throughout the week as we get updates on various injuries across the league along with betting limits increasing as the week progresses.
Below, we take a look at the latest odds for Week 3 from Caesars Sportsbook along with a couple of bets to consider for this Sunday.
NFL odds Week 3
Odds courtesy of Caesars Sportsbook
| Game | Spread |
| Cleveland Browns vs. Pittsburgh Steelers | CLE -4 (+100) |
| Miami Dolphins vs. Buffalo Bills | MIA +4.5 (-110) |
| New England Patriots vs. Baltimore Ravens | NE +2.5 (+100) |
| Washington Commanders vs. Philadelphia Eagles | WSH +6.5 (-110) |
| Indianapolis Colts vs. Kansas City Chiefs | IND +5 (-110) |
| Carolina Panthers vs. New Orleans Saints | CAR +2 (-110) |
| Tennessee Titans vs. Las Vegas Raiders | TEN +2 (-110) |
| Minnesota Vikings vs. Detroit Lions | MIN -6 (-110) |
| Chicago Bears vs. Houston Texans | CHI -3 (-120) |
| New York Jets vs. Cincinnati Bengals | NYJ +6 (-110) |
| Tampa Bay Buccaneers vs. Green Bay Packers | TB -1.5 (-110) |
| Los Angeles Chargers vs. Jacksonville Jaguars | LAC -3.5 (-120) |
| Arizona Cardinals vs. Los Angeles Rams | ARI +3.5 (-110) |
| Seattle Seahawks vs. Atlanta Falcons | SEA -1 (-110) |
| Denver Broncos vs. San Francisco 49ers | DEN +1.5 (-110) |
| New York Giants vs. Dallas Cowboys | NYG -1 (-110) |
NFL money lines Week 3
| Game | Moneyline |
| Cleveland Browns vs. Pittsburgh Steelers | CLE -205 | PIT +170 |
| Miami Dolphins vs. Buffalo Bills | BUF -205 | MIA +170 |
| New England Patriots vs. Baltimore Ravens | BAL -145 | NE +122 |
| Washington Commanders vs. Philadelphia Eagles | PHI -285 | WSH +228 |
| Indianapolis Colts vs. Kansas City Chiefs | KC -235 | IND +192 |
| Carolina Panthers vs. New Orleans Saints | NO -135 | CAR +115 |
| Tennessee Titans vs. Las Vegas Raiders | LV -130 | TEN +110 |
| Minnesota Vikings vs. Detroit Lions | MIN -250 | DET +205 |
| Chicago Bears vs. Houston Texans | CHI -155 | HOU +130 |
| New York Jets vs. Cincinnati Bengals | CIN -267 | NYJ +215 |
| Tampa Bay Buccaneers vs. Green Bay Packers | TB -120 | GB +100 |
| Los Angeles Chargers vs. Jacksonville Jaguars | LAC -190 | JAX +158 |
| Arizona Cardinals vs. Los Angeles Rams | LAR -190 | ARI +158 |
| Seattle Seahawks vs. Atlanta Falcons | SEA -115 | ATL -105 |
| Denver Broncos vs. San Francisco 49ers | SF -125 | DEN +105 |
| New York Giants vs. Dallas Cowboys | NYG -115 | DAL -105 |
NFL over/unders Week 3
| Game | Total |
| Cleveland Browns vs. Pittsburgh Steelers | 38 |
| Miami Dolphins vs. Buffalo Bills | 53.5 |
| New England Patriots vs. Baltimore Ravens | 44.5 |
| Washington Commanders vs. Philadelphia Eagles | 47.5 |
| Indianapolis Colts vs. Kansas City Chiefs | 51 |
| Carolina Panthers vs. New Orleans Saints | 41 |
| Tennessee Titans vs. Las Vegas Raiders | 45.5 |
| Minnesota Vikings vs. Detroit Lions | 52 |
| Chicago Bears vs. Houston Texans | 39 |
| New York Jets vs. Cincinnati Bengals | 45.5 |
| Tampa Bay Buccaneers vs. Green Bay Packers | 42 |
| Los Angeles Chargers vs. Jacksonville Jaguars | 42.5 |
| Arizona Cardinals vs. Los Angeles Rams | 48.5 |
| Seattle Seahawks vs. Atlanta Falcons | 43.5 |
| Denver Broncos vs. San Francisco 49ers | 44.5 |
| New York Giants vs. Dallas Cowboys | 39 |
NFL best bets for Week 3
Odds as of Monday (9/19) at 3:30 p.m. ET
Vikings-Lions UNDER 52.5 points (-110)
While we've yet to see what the Vikings offense does in Week 1 following an impressive performance in Kevin O'Connell's first game as head coach, and even without knowing the Vikings' Week 2 result, this total seems a bit inflated. On the surface, Detroit appears to be an offensive juggernaut through the first two weeks, scoring 35 and 36 total points to begin the season. It's a bit misleading given they were forced into a pass-heavy approach while trailing by multiple scores in their Week 1 loss to Philadelphia and took advantage of a subpar Commanders defense in Week 2. Look for the Vikings' defense to hold the Lions' offense in check, leading this game to fall UNDER the current total of 52.5 points.
Eagles -4 (-110) at Commanders
It's always tough laying over a field goal on a road favorite, but Philadelphia has the ability to notch a TD-plus road win in Washington. There's a high likelihood this line moves a bit following Philadelphia's Week 2 result, with the line likely inching closer to a field goal if the Eagles don't impress on Monday Night Football, but moving closer to a touchdown if they do impress for a second-straight week. It's part of the gamble, but we'll side towards the latter hoping this line closes closer to a touchdown. Washington's defense had issues against Detroit and we don't think Carson Wentz does enough to keep the Commanders within striking distance against the franchise that drafted him No. 2 overall back in 2016.
Raiders -1 (-110) at Titans
For our last wager, we'll back Josh McDaniels and the Raiders to get their first victory of the season on the road in Tennessee. The Titans will more than likely also enter Week 2 with a 0-2 record, making this game truly a "must-win" for both teams. Both teams have had epic second-half implosions in the early season, but regardless of those results, the Raiders are still power-rated ahead of Tennessee at the moment. Had Randy Bullock not missed a potential game-winning field goal and Hunter Renfrow not fumbled, these teams wouldn't be in a "must-win" situation, but like always the margin for error is beyond slim in the NFL.