The road to Super Bowl 60 has begun, as the 2025 NFL season prepares for kick-off.
Just under six months on from the Philadelphia Eagles' triumph in Super Bowl 59, the Detroit Lions and Los Angeles Chargers got preseason off and running with the Hall of Fame Game in Canton, Ohio.
The 2025 season will once again see three games in London featuring six different teams, all taking place in three consecutive weeks. Two of those games will be played at Tottenham Hotspur Stadium, before the final game will move to Wembley Stadium for the London series finale.
With the start of the new season only a few weeks away, fans both Stateside and closer to home are already preparing their picks and assessing the challengers from each conference. The task? Plot a path to Levi's Stadium in Santa Clara, California on February 8, 2026 and a date at the Super Bowl.
But who will follow in the footsteps of the Eagles and emerge as the pre-eminent team in the NFL? The Sporting News has all the early odds and contenders for the new season.
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NFL preseason schedule 2025: Dates, times, TV channels, live streams
Preseason is unlikely to alter the odds too much, as most of the star players will likely be limited to playing little more than a few quarters across the entire schedule.
But it can still provide something of a window into which teams look in good shape to challenge in 2025/26.
NFL preseason schedule 2025: Dates, times, tv channels, live streams for every game
NFL 2025/26 Super Bowl odds, betting and predictions
The Eagles will have no shortage of challengers after thwarting the Kansas City Chiefs' bid for a three-peat in February, their win serving as a reminder to the rest of the NFL that Patrick Mahomes can be defeated on the biggest stage. With the Chiefs having attacked the issues that proved their downfall and, with multiple teams aiming to follow the Eagles' blueprint, the road to Super Bowl 60 promises to be as competitive as ever.
At least one of the Eagles or Chiefs has contested six of the last eight Super Bowls. The Eagles remain the favourites in the NFC, but the top two teams in the odds heading into preseason are the Baltimore Ravens and the Buffalo Bills.
That makes some sense, as it's exceedingly rare for the same teams to make the Big Game in two consecutive years. And, before the Chiefs won two in a row in 2023 and '24, the last team to repeat was the New England Patriots in '04 and '05.
What do the experts think? Well when it comes to early championship picks, our team of seasoned US Sports writers were divided.
The Sporting News' Vinnie Iyer backed The Eagles. After their Super Bowl win back in February he noted on their 2025/26 prospects: "Jalen Hurts and Saquon Barkley will bring back a loaded offense, and the defense is young enough in key spots to think it will maintain its strength. Philadelphia now has the game's best young coach in Nick Sirianni and Hurts' rise to elite play as Super Bowl MVP gives the team a high ceiling."
Meanwhile, Bill Bender also favours the reigning champions, adding: "Philadelphia is the most consistent team in the NFC in the postseason, although the Eagles will have to fend off the usual contenders again — the Commanders in the NFC East, and the Lions, 49ers and Packers outside the division."
For those seeking an alternative pick, though, look no further than our very own Sloan Piva, who has predicted the Bills to claim the Vince Lombardi Trophy.
He said: "Buffalo made great strides in 2024, fuelled by the heroics of first-time MVP Josh Allen and second-time Pro Bowl running back James Cook. With even one star wideout, Sean McDermott's squad probably would have made Super Bowl 59.
"The Bills have a solid offensive line, a promising defense that will be potent with some pass-rushing reinforcements, and a fairly friendly 2025/26 schedule. Buffalo might finally win its first Super Bowl."
Below are the latest odds for the 2025/26 season, and the teams' various records in 2024/25 for comparison.
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| Team | Odds* (via 10bet) | 2024 Record (W-L) |
| Baltimore Ravens | 6/1 | 12-5 |
| Buffalo Bills | 13/2 | 13-4 |
| Philadelphia Eagles | 7/1 | 14-3 |
| Kansas City Chiefs | 8/1 | 15-2 |
| Detroit Lions | 11/1 | 15-2 |
| Washington Commanders | 18/1 | 12-5 |
| Green Bay Packers | 20/1 | 11-6 |
| Los Angeles Rams | 20/1 | 10-7 |
| San Francisco 49ers | 20/1 | 6-11 |
| Cincinnati Bengals | 22/1 | 9-8 |
| Minnesota Vikings | 25/1 | 14-3 |
| Los Angeles Chargers | 28/1 | 11-6 |
| Denver Broncos | 28/1 | 10-7 |
| Tampa Bay Buccaneers | 28/1 | 10-7 |
| Houston Texans | 30/1 | 10-7 |
| Chicago Bears | 33/1 | 5-12 |
| Pittsburgh Steelers | 33/1 | 10-7 |
| Dallas Cowboys | 50/1 | 7-10 |
| Arizona Cardinals | 50/1 | 8-9 |
| Seattle Seahawks | 55/1 | 10-7 |
| New England Patriots | 70/1 | 4-13 |
| Jacksonville Jaguars | 70/1 | 4-13 |
| Atlanta Falcons | 70/1 | 8-9 |
| Miami Dolphins | 90/1 | 8-9 |
| Indianapolis Colts | 100/1 | 8-9 |
| Las Vegas Raiders | 100/1 | 4-13 |
| Carolina Panthers | 125/1 | 5-12 |
| New York Giants | 150/1 | 3-14 |
| Tennessee Titans | 200/1 | 3-14 |
| New York Jets | 250/1 | 5-12 |
| Cleveland Browns | 300/1 | 3-14 |
| New Orleans Saints | 400/1 | 5-12 |
* Odds correct at time of publish and subject to change