Germany will be without midfielder Sami Khedira for Friday's World Cup qualifier against Czech Republic.
The Juventus man is believed to have suffered a knee injury and will not be risked for the meeting in Prague.
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Germany hope to have the 30-year-old available for Monday's game against Norway, so he will remain with the squad.
The news comes after winger Serge Gnabry was forced to withdraw from Joachim Low's plans as a result of an ankle ligament problem.
The 22-year-old, on loan at Hoffenheim from Bayern Munich, will not be fit for either match and returned home from the team hotel in Stuttgart on Tuesday.
Germany sit top of Group C with four games left to play, having won each of their six encounters so far.