The Top 25 saw arguably its biggest shakeup of the season on Saturday, with several ranked teams falling — including three in top-10 matchups.
The biggest game on paper was the "Game of the Century" between No. 1 Georgia and No. 2 Tennessee in Athens. The Bulldogs methodically ended any chance the Volunteers had of winning, however, stymying Hendon Hooker and Co. in a grind-it-out 27-13 victory.
The game between No. 6 Alabama and No. 15 LSU was certainly more entertaining, as the teams battled in a back-and-forth affair that saw the Tigers win 32-31 on a gutsy 2-point conversion attempt in overtime. With that, the Crimson Tide will miss the College Football Playoff for only the second time since its inception in 2014. LSU, meanwhile, is atop the SEC West division and eyeing a meeting with Georgia in the SEC Championship Game.
The lone top-10 team to fall to an unranked opponent was No. 5 Clemson, which was manhandled by unranked Notre Dame in a 35-14 blowout. DJ Uiagalelei was again benched, but not even backup Cade Klubnik could lead the Tigers back against the Fighting Irish.
MORE: College football rankings: How Tennessee, Alabama, Clemson losses impact playoff race
Those weren't the only ranked teams to lose on Saturday: No. 13 Kansas State, No. 14 Illinois, No. 18 Oklahoma State, No. 20 Wake Forest, No. 22 Syracuse and No. 24 Oregon State all fell in Week 10 as well.
How will those losses affect the latest AP Top 25 and Coaches Poll rankings? Here are the latest rankings after Week 10:
MORE: College Football Playoff ranking schedule, release dates for 2022
College football rankings for Week 10
Coaches Poll
| Rank | Team | Record | Points (No. 1 votes) |
| 1 | Georgia | 9-0 | 1,572 (61) |
| 2 | Ohio State | 9-0 | 1,505 |
| 3 | Michigan | 9-0 | 1,447 (2) |
| 4 | TCU | 9-0 | 1,335 |
| 5 | Tennessee | 8-1 | 1,284 |
| 6 | Oregon | 8-1 | 1,271 |
| 7 | USC | 8-1 | 1,140 |
| 8 | LSU | 7-2 | 1,082 |
| 9 | Ole Miss | 8-1 | 1,056 |
| 10 | UCLA | 8-1 | 988 |
| 11 | Alabama | 7-2 | 973 |
| 12 | Clemson | 8-1 | 896 |
| 13 | Utah | 7-2 | 888 |
| 14 | North Carolina | 8-1 | 737 |
| 15 | Penn State | 7-2 | 717 |
| 16 | N.C. State | 7-2 | 568 |
| 17 | Tulane | 8-1 | 555 |
| 18 | Texas | 6-3 | 368 |
| 19 | Liberty | 8-1 | 366 |
| 20 | Illinois | 7-2 | 302 |
| 21 | UCF | 7-2 | 273 |
| 22 | Kansas State | 6-3 | 243 |
| 23 | Washington | 7-2 | 175 |
| 24 | Kentucky | 6-3 | 173 |
| 25 | Notre Dame | 6-3 | 133 |
Others receiving votes: Coastal Carolina 77; Cincinnati 70; Wake Forest 53; Oklahoma State 53; Baylor 46; Florida State 22; Syracuse 20; Kansas 12; Mississippi State 11; Troy 10; Louisville 9; UTSA 6; Pitt 4; Minnesota 4; South Carolina 3; Oregon State 3; Maryland 3; Boise State 1.
MORE: Week 10 College Football Playoff rankings
AP Top 25
This section will be updated when the AP Top 25 releases.
| Rank | Team | Record | Points (No. 1 votes) |
| 1 | Georgia | 9-0 | 1,574 (62) |
| 2 | Ohio State | 9-0 | 1,500 (1) |
| 3 | Michigan | 9-0 | 1,455 |
| 4 | TCU | 9-0 | 1,361 |
| 5 | Tennessee | 8-1 | 1,339 |
| 6 | Oregon | 8-1 | 1,258 |
| 7 | LSU | 8-1 | 1,132 |
| 8 | USC | 7-2 | 1,061 |
| 9 | UCLA | 8-1 | 1,040 |
| 10 | Alabama | 7-2 | 1,009 |
| 11 | Ole Miss | 8-1 | 962 |
| 12 | Clemson | 8-1 | 938 |
| 13 | Utah | 7-2 | 881 |
| 14 | Penn State | 8-2 | 735 |
| 15 | North Carolina | 8-1 | 676 |
| 16 | Tulane | 8-1 | 607 |
| 17 | N.C. State | 7-2 | 547 |
| 18 | Texas | 6-3 | 399 |
| 19 | Liberty | 8-1 | 358 |
| 20 | Notre Dame | 6-3 | 316 |
| 21 | Illinois | 7-2 | 262 |
| 22 | UCF | 7-2 | 257 |
| 23 | Kansas State | 6-3 | 247 |
| 24 | Washington | 7-2 | 187 |
| 25 | Florida State | 6-3 | 78 |
Others receiving votes: Cincinnati 74; Kentucky 61; Coastal Carolina 46; Wake Forest 34; Oklahoma State 21; Baylor 19; Kansas 10; Mississippi State 8; South Carolina 6; Troy 5; UTSA 5; Louisville 3; Oregon State 3; San Jose State 1.