Cody Walker is set for another spell on the sidelines.
The Rabbitohs playmaker sustained a calf tear at training this week, the club confirmed on Thursday.
He is expected to miss approximately five weeks of action.
This means Walker will miss Friday's clash with the Storm, and is in line to sit out matches against the Knights, Broncos, Tigers and Warriors.
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As a result, Bunnies coach Wayne Bennett has shifted his team around for ANZAC Day.
Jye Gray, who was originally moved from fullback to the pine to accommodate Latrell Mitchell, will partner Jayden Sullivan in the halves against Melbourne.
Super League recruit Lewis Dodd is likely to be promoted to the bench utility role.
New halves duo Gray and Sullivan have a significant challenge ahead of them in Round 8, with Souths yet to record a win in 19 trips to Victoria's capital.
"No, he [Walker] is not playing. He’s hurt his calf, got a severe tear there training two days ago, three days ago, so he’ll be out for four or five weeks," Bennett said.
"Jye Gray will come in, and Latrell will be the captain ... that was his [Gray] junior position.
"All his senior football has been at fullback, but I’m confident he can do the job for us."
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Walker was sidelined earlier this season with a hamstring injury.
This recent calf tear is on his other leg, though.
Fellow playmaker Jamie Humphreys also remains out with a hamstring issue, but could return in two to three weeks.