Will the axe swing at several embarrassed clubs, including Essendon, Brisbane, North Melbourne, Port Adelaide and Melbourne?
MORE: All the latest AFL injury news
Read on for all the latest round 21 team news and tips:
Western Bulldogs vs. GWS team news, selection, injuries
Western Bulldogs
On the Chopping Block: Lachlan McNeil, Laitham Vandermeer, Caleb Poulter, Oskar Baker
New injuries: None
Facing fitness test: None
Potential ins: Buku Khamis, Sam Davidson, James Harmes, Michael Sellwood, Arthur Jones
GWS
On the Chopping Block: Toby McMullin
New injuries: Jack Buckley (calf), Josh Kelly (calf), Toby Greene (suspended)
Facing fitness test: None
Potential ins: Leek Aleer, Jacob Wehr, Harry Rowston, Josh Fahey, Harvey Thomas, Max Gruzewski
Adelaide vs. Hawthorn team news, selection, injuries
Adelaide
On the Chopping Block: Chayce Jones, Luke Pedlar, Zac Taylor, Brayden Cook
New injuries: Max Michalanney (hamstring)
Facing fitness test: None
Potential ins: Isaac Cumming, Hugh Bond
Hawthorn
On the Chopping Block: Bailey Macdonald
New injuries: None
Facing fitness test: Mabior Chol (groin)
Potential ins: Max Ramsden, Cam McKenzie, Jai Serong
Melbourne vs. West Coast team news, selection, injuries
Melbourne
On the Chopping Block: Charlie Spargo, Harrison Petty, Caleb Windsor, Daniel Turner
New injuries: None
Facing fitness test: Jack Henderson (groin)
Potential ins: Harry Sharp, Koltyn Tholstrup, Jack Billings, Bailey Laurie
West Coast
On the Chopping Block: Tyrell Dewar, Archer Reid, Matthew Owies
New injuries: Harley Reid (ankle)
Facing fitness test: Harry Edwards (hamstring)
Potential ins: Campbell Chesser, Lucca Grego, Jacob Newton, Tom Gross, Loch Rawlinson
Gold Coast vs. Richmond team news, selection, injuries
Gold Coast
On the Chopping Block: Oscar Adams, Leonardo Lombard, Nick Holman
New injuries: None
Facing fitness test: Will Graham (shoulder), Touk Miller (hamstring)
Potential ins: Jed Walter, Ben Jepson, Zak Evans
Richmond
On the Chopping Block: Jasper Alger, Maurice Rioli, Thomas Sims, James Trezise
New injuries: None
Facing fitness test: Tim Taranto (calf), Seth Campbell (concussion)
Potential ins: Harry Armstrong, Jacob Koschitzke, Jacob Blight
Sydney vs. Essendon team news, selection, injuries
Sydney
On the Chopping Block: Braeden Campbell, Jack Buller
New injuries: Hayden McLean (concussion), Joel Hamling (hamstring)
Facing fitness test: Tom McCartin (concussion)
Potential ins: Aaron Francis, Peter Ladhams, Jesse Dattoli, Caiden Cleary, Corey Warner
Essendon
On the Chopping Block: Oskar Smartt, Archie Perkins, Angus Clarke, Zak Johnson, Luamon Lual
New injuries: Jordan Ridley (hamstring)
Facing fitness test: Ben Hobbs (groin)
Potential ins: Archer May, Kayle Gerreyn, Jayden Nguyen, Alwyn Davey Jnr, Jye Menzie
Collingwood vs. Brisbane team news, selection, injuries
Collingwood
On the Chopping Block: Oleg Markov, Ed Allan, Charlie Dean
New injuries: Lachlan Sullivan (knee)
Facing fitness test: None
Potential ins: Scott Pendlebury, Bobby Hill, Jordan De Goey, Billy Frampton
Brisbane
On the Chopping Block: Oscar McInerney
New injuries: Conor McKenna (hamstring)
Facing fitness test: None
Potential ins: Will McLachlan, Bruce Reville, Sam Day, Henry Smith
St Kilda vs. North Melbourne team news, selection, injuries
St Kilda
On the Chopping Block: Ryan Byrnes, Arie Schoenmaker
New injuries: None
Facing fitness test: Lance Collard (corky), Jack Carroll (knee), Hugo Garcia (wrist), Isaac Keeler (hamstring), Mattaes Phillipou (calf), Darcy Wilson (concussion)
Potential ins: Tobie Travaglia, Max Heath, Paddy Dow
North Melbourne
On the Chopping Block: Robert Hansen Jnr, Jacob Konstanty, Will Dawson, Finnbar Maley, Zac Banch, Zane Duursma
New injuries: None
Facing fitness test: Nick Larkey (knee)
Potential ins: Cooper Harvey, George Wardlaw, Will Phillips, Zac Fisher, Cooper Trembath, Eddie Ford
Geelong vs. Port Adelaide team news, selection, injuries
Geelong
On the Chopping Block: Jack Martin
New injuries: None
Facing fitness test: None
Potential ins: Jhye Clark, George Stevens
Port Adelaide
On the Chopping Block: Hugh Jackson, Ollie Lord, Darcy Byrne-Jones, Joe Berry, Logan Evans
New injuries: Jack Lukosius (calf)
Facing fitness test: Lachie Jones (corkie)
Potential ins: Jack Whitlock, Dylan Williams, Will Lorenz, Mani Liddy, Willie Rioli
Fremantle vs. Carlton team news, selection, injuries
Fremantle
On the Chopping Block: Neil Erasmus, Nathan O'Driscoll
New injuries: None
Facing fitness test: James Aish (back), Nat Fyfe (calf), Alex Pearce (shin), Corey Wagner (heel)
Potential ins: Cooper Simpson, Brandon Walker, Quinton Narkle, Will Brodie
Carlton
On the Chopping Block: Corey Durdin, Lachie Fogarty
New injuries: None
Facing fitness test: Flynn Young (foot), Francis Evans (concussion)
Potential ins: Jaxon Binns, Jordan Boyd, Hudson O'Keeffe, Billy Watson