Four Essendon players have been ruled out of Thursday night's clash with GWS, including two stars.
However, the Giants will be missing two guns of their own.
Premiership favourite Collingwood will regain two key cogs but lose a veteran in defence.
MORE: All the latest AFL injury news
Read on for all the latest round 19 team news and tips:
Essendon vs. GWS team news, selection, injuries
Essendon
On the Chopping Block: Angus Clarke, Oskar Smartt, Luamon Lual
New injuries: Nic Martin (knee), Will Setterfield (foot), Nate Caddy (soreness), Ben Hobbs (groin)
Facing fitness test: None
Potential ins: Liam McMahon, Jade Gresham, Archie Perkins, Saad El-Hawli, Dylan Shiel, Matt Guelfi
GWS
On the Chopping Block: None
New injuries: Jesse Hogan (foot), Josh Kelly (hip)
Facing fitness test: None
Potential ins: Max Gruzewski, Stephen Coniglio, Jacob Wehr
Brisbane vs. Western Bulldogs team news, selection, injuries
Brisbane
On the Chopping Block: Darcy Fort
New injuries: Noah Answerth (Achilles), Zac Bailey (suspended)
Facing fitness test: None
Potential ins: Sam Day, Keidean Coleman, Bruce Reville
Western Bulldogs
On the Chopping Block: Cooper Hynes, Caleb Poulter, Josh Dolan
New injuries: None
Facing fitness test: James Harmes (illness)
Potential ins: Liam Jones, Jed Busslinger, Michael Sellwood
Hawthorn vs. Port Adelaide team news, selection, injuries
Hawthorn
On the Chopping Block: Cam McKenzie, Finn Maginness
New injuries: None
Facing fitness test: Sam Butler (leg), Sam Mitchell (ankle)
Potential ins: Mitch Lewis, Mac Ramsden, Henry Hustwaite, Jack Scrimshaw
Port Adelaide
On the Chopping Block: Will Lorenz, Jack Lukosius, Ollie Lord
New injuries: Jason Horne-Francis (foot)
Facing fitness test: Connor Rozee (test)
Potential ins: Dylan Williams, Josh Lai, Christian Moraes, Joe Berry, Logan Evans
Sydney vs. North Melbourne team news, selection, injuries
Sydney
On the Chopping Block: Aaron Francis, Joel Hamling
New injuries: Tom McCartin (concussion)
Facing fitness test: Robbie Fox, Dane Rampe
Potential ins: Ollie Florent, Caiden Cleary
North Melbourne
On the Chopping Block: Finnbar Maley, Bailey Scott, Robert Hansen Jr
New injuries: Tristian Xerri (suspension)
Facing fitness test: Luke Davies-Uniacke, Luke McDonald
Potential ins: Callum Coleman-Jones, George Wardlaw, Brynn Teakle
Carlton vs. Melbourne team news, selection, injuries
Carlton
On the Chopping Block: Cooper Lord, Alex Cincotta, Lachie Fogarty
New injuries: Mitch McGovern (hamstring), Orazio Fantasia (hamstring)
Facing fitness test: None
Potential ins: Francis Evans, Will White, Billy Wilson, Blake Acres, Harry Lemmey
Melbourne
On the Chopping Block: Caleb Windsor, Xavier Lindsay, Koltyn Tholstrup, Matthew Jefferson
New injuries: Tom Sparrow (concussion), Jake Lever (ankle)
Facing fitness test: Aidan Johnson, Harry Petty
Potential ins: Steven May, Jack Billings, Blake Howes, Harry Sharp
West Coast vs. Richmond team news, selection, injuries
West Coast
On the Chopping Block: Noah Long, Bailey Williams, Malakai Champion, Rhett Bazzo
New injuries: None
Facing fitness test: Liam Ryan (soreness)
Potential ins: Sandy Brock, Bo Allan, Jayden Hunt, Archer Reid, Tom Gross
Richmond
On the Chopping Block: Rhyan Mansell, Jacob Koschitzke
New injuries: None
Facing fitness test: None
Potential ins: Steely Green, Jacob Blight, Josh Gibcus, Harry Armstong, Jasper Alger
Geelong vs. St Kilda team news, selection, injuries
Geelong
On the Chopping Block: Oliver Henry, Rhys Stanley, George Stevens
New injuries: None
Facing fitness test: Sam De Koning (shoulder), Lenny Hofmann (hamstring)
Potential ins: Ted Clohesy, Jhye Clark, Jacob Molier
St Kilda
On the Chopping Block: Hugh Boxshall, Liam Henry
New injuries: Dan Butler (elbow)
Facing fitness test: None
Potential ins: Alex Dodson, Darcy Wilson, Paddy Dow
Collingwood vs. Fremantle team news, selection, injuries
Collingwood
On the Chopping Block: Mason Cox, Roan Steele, Lachlan Sullivan, Oleg Markov
New injuries: Jeremy Howe (groin)
Facing fitness test: Lachie Schultz (hamstring), Billy Frampton (calf), Beau McCreery (hamstring)
Potential ins: Brody Mihocek, Pat Lipinski, Ed Allan, Charlie Dean, Noah Howes
Fremantle
On the Chopping Block: Isaiah Dudley, Bailey Banfield
New injuries: None
Facing fitness test: Hayden Young, Will Brodie
Potential ins: Brandon Walker
Adelaide vs. Gold Coast team news, selection, injuries
Adelaide
On the Chopping Block: Zac Taylor, Chayce Jones, Sam Berry
New injuries: Jordon Butts (chest), Brayden Cook (concussion)
Facing fitness test: None
Potential ins: Nick Murray, Luke Pedlar, Lachie Murphy, Sid Draper, Luke Nankervis
Gold Coast
On the Chopping Block: Oscar Adams, Connor Budarick, Wil Powell
New injuries: Touk Miller (hamstring)
Facing fitness test: Sam Collins (calf), Caleb Graham (Achilles)
Potential ins: Leo Lombard, Jake Rogers, Malcolm Rosas, Nick Holman