Collingwood are set to swing the changes with a VFL goalkicking machine to make his debut.
Hawthorn could get two guns back, while their spearhead returns to the twos after an ACL injury.
The Blues are tipped to have a couple of debutants of their own as they attempt to change their fortunes.
MORE: All the latest AFL injury news
Read on for all the latest round 16 team news and tips:
Port Adelaide vs. Carlton team news, selection, injuries
Two big ins at either end of the ground for Port, with Aliir Aliir and Jack Lukosius ready to go.
That could trigger a shuffle in the ruck combination of Jordon Sweet and Dante Visentini, with one to perhaps drop out, while last week's sub Jeremy Finlayson could also be relieved of his spot.
Joe Berry was a late out ahead of the loss to Sydney and could replace Christian Moraes, who was quiet last week.
The Blues are under the pump following their defeat to North Melbourne, with the Cooper Lord, Corey Durdin, Alex Cincotta and Matt Carroll sure to be looking over their shoulders.
In the VFL, Billy Wilson, Ben Camporeale and Flynn Young all pushed their cases strongly for a senior berth.
Sydney vs. Western Bulldogs team news, selection, injuries
The Swans successfully welcomed Tom Papley and Errol Gulden back from injury last week and are unlikely to make too many changes, although Aaron Francis could miss out after being subbed out for tactical reasons last week.
Robbie Fox may have to bide his time in the reserves if he's to return from concussion, while Jake Lloyd responded to his dropping with 38 touches.
Caiden Cleary and Ollie Florent also got plenty of the footy in the VFL to ensure they remain in contention for a recall.
The Dogs lose Adam Treloar to another calf injury, which should pave the way for Ryley Sanders to come back into the team after being withdrawn with illness ahead of the win over Richmond.
Riley Garcia, Taylor Duryea, Jedd Busslinger and Jason Johannisen were all strong in the twos, although the only avenue into the side could be if James O'Donnell fails a fitness test on an adductor concern.
Gold Coast vs. Melbourne team news, selection, injuries
No imminent injury returns for the Suns could mean they go in unchanged despite a three-loss skid.
In the VFL, Leo Lombard and David Swallow pushed their cases, with Connor Budarick perhaps the most likely to drop out.
Jed Walter and Mac Andrew were also poor against the Giants if Damien Hardwick wants to make a statement at the selection table.
Coming off the bye, the Demons will be looking to bounce back from their own run of three-straight defeats.
In the loss to Port Adelaide a fortnight ago, Jake Melksham and Tom Sparrow were well held, leaving the door open for someone like Bailey Laurie, Koltyn Tholstrup, Harry Sharp or Matt Jefferson to come in.
Hawthorn vs. North Melbourne team news, selection, injuries
Coming off their mid-season bye, Hawthorn has both James Sicily (hip) and James Worpel (corked leg) to face fitness tests.
However, Jack Scrimshaw (hamstring) is likely to held out for at least another week.
The axe could come for any of young trio Max Ramsden, Seamus Mitchell and Henry Hustwaite.
Spearhead Mitch Lewis (ACL) makes his return to the VFL in a hugely encouraging development for the Hawks' future forward line.
Expect North Melbourne to remain unchanged if Charlie Comben (shoulder) and Jack Darling (leg) are passed fit, which is expected.
Will Phillips, Wil Dawson and Finnbar Maley were among the best players in the VFL.
Collingwood vs. West Coast team news, selection, injuries
The Magpies are flying but they have already confirmed a debutant in Charlie West - who has kicked 25 goals in 10 games this season and six in his most recent match.
Beau McCreery (hamstring) is tipped to miss the next three weeks, while Billy Frampton (calf) will also need to be replaced.
Brayden Maynard (foot) seems destined for a return and Tom Mitchell continues to put his hand up through strong VFL performances.
Harley Reid is rumoured to be struggling with a back issue for West Coast with a test destined later this week.
The Eagles will lose Oscar Allen (calf) for the rest of the season, while Tom Cole (hamstring) is also going to miss.
Jeremy McGovern's medical retirement from concussion is a huge blow to West Coast, while Harry Edwards (hamstring) might not fill a defensive role if he doesn't pass a test.
Richmond vs. Adelaide team news, selection, injuries
Expect Adem Yze to ring the changes with Richmond putting together an uncompetitive performance against the Bulldogs.
After six weeks off, Jayden Short (calf) should return, while Jacob Blight and Mykelti Lefau look set to earn senior selection after solid VFL form.
A swag of players look set for a spell in the twos including Kaleb Smith, Tyler Sonsie, Jonty Faull and Thomas Sims, while Jasper Alger was the sub and didn't have much impact.
Sam Lalor (hamstring) is closing in on a return but might get another week on the sidelines to make sure, while Noah Balta can play despite his curfew as the match is a 3:20pm start.
James Peatling (suspension) should be injected into Adelaide's team after they had their mid-season bye.
It's hard to see who could be dropped but Luke Pedlar seems to be right on the edge.
Both Sid Draper and Zac Taylor are pushing for selection but are struggling to get a spot in the senior team.
Fremantle vs. St Kilda team news, selection, injuries
The Dockers and up-and-going so it's hard to see Justin Longmuir making too many changes.
The big decision will be around whether Sean Darcy comes back in after being managed.
Luke Jackson seems to be thriving with the responsibility of being the no.1 ruckman.
There have been impressive recent WAFL performances from Jaeger O'Meara, while Brandon Walker (shoulder) returned at that level last week from injury.
Michael Walters has been another to slowly build their match fitness in the twos.
Alex Pearce (shin) is close to a return after not playing since Round 11, but will need to pass a fitness test.
St Kilda put in a much-improved performance against Collingwood but still came up well-short as the Magpies kicked away.
Ryan Byrnes filled in after the late scratching of Matteas Phillipou (calf), who will be out for 3-4 weeks, but failed to make a strong impression on the game.
Jimmy Webster and Isaac Keeler both had quiet matches versus Collingwood, but players to replace them aren't really putting their hand up at VFL level.
Hugo Garcia and Zak Jones were among the best players in the VFL, but Jones may have his papers stamped after failing to perform at senior level consistently.
The likes of Hugh Boxshall, Jack Carroll and Liam Henry could be called upon if Ross Lyon decides to make changes.